Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Prdx6tm1Abf
Name:	peroxiredoxin 6; targeted mutation 1, Aron B Fisher
MGI ID:	MGI:2683326
Synonyms:	1-cysPrx -
Gene:	Prdx6  Location: Chr1:161067682-161078780 bp, - strand  Genetic Position: Chr1, 69.75 cM
Alliance:	Prdx6tm1Abf page

Germline Transmission:	Earliest citation of germline transmission: J:86750
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Part of intron 2 and the first part of exon 3 were replaced by a neomycin resistance gene in the reverse orientation. Lack of gene product in homozygotes was demonstrated by both real-time PCR and Western blot analysis. (J:86750)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Prdx6 Mutation:	52 strains or lines available

Original:	J:86750 Mo Y, et al., 1-Cys peroxiredoxin knock-out mice express mRNA but not protein for a highly related intronless gene. FEBS Lett. 2003 Dec 4;555(2):192-8
All:	22 reference(s)