About   Help   FAQ
Cdc25btm1Pjd
Targeted Allele Detail
Summary
Symbol: Cdc25btm1Pjd
Name: cell division cycle 25B; targeted mutation 1, Peter J Donovan
MGI ID: MGI:2682953
Synonyms: Cdc25b-
Gene: Cdc25b  Location: Chr2:131028869-131040417 bp, + strand  Genetic Position: Chr2, 63.29 cM
Alliance: Cdc25btm1Pjd page
Shortened villi in the small intestine of Cdc25atm1Hpw/Cdc25atm1.1Hpw Cdc25btm1Pjd/Cdc25btm1Pjd Cdc25ctm1Hpw/Cdc25ctm1Hpw Gt(ROSA)26Sortm1(cre/ERT)Brn/Gt(ROSA)26Sor+ (TKO) mice

Show the 4 phenotype image(s) involving this allele.

Mutation
origin
Germline Transmission:  Earliest citation of germline transmission: J:87011
Parent Cell Line:  Not Specified (ES Cell)
Strain of Origin:  Not Specified
Mutation
description
Allele Type:    Targeted (Null/knockout)
Mutations:    Insertion, Intragenic deletion
 
Mutation detailsA 4.0 kb region encoding the phosphatase box was replaced with a neomycin selection cassette inserted by homologous recombination. Protein was undetected by Western blot analysis of homozygous mutant MEF extracts using an N-terminal antibody. (J:87011)
Phenotypes
Loading...
View phenotypes and curated references for all genotypes (concatenated display).
Expression
In Structures Affected by this Mutation: 2 anatomical structure(s)
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Cdc25b Mutation:  30 strains or lines available
References
Original:  J:87011 Lincoln AJ, et al., Cdc25b phosphatase is required for resumption of meiosis during oocyte maturation. Nat Genet. 2002 Apr;30(4):446-9
All:  5 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
Citing These Resources
Funding Information
Warranty Disclaimer, Privacy Notice, Licensing, & Copyright
Send questions and comments to User Support.
last database update
03/19/2024
MGI 6.23
The Jackson Laboratory