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Tg(Ins2-CD80)3B7Flv
Transgene Detail
Summary
Symbol: Tg(Ins2-CD80)3B7Flv
Name: transgene insertion 3B7, Richard Flavell
MGI ID: MGI:2682826
Synonyms: RIP-B7, RIP-B7-1, RIP-B7.1, RIP-CD80
Transgene: Tg(Ins2-CD80)3B7Flv  Location: unknown  
Alliance: Tg(Ins2-CD80)3B7Flv page
Transgene
origin
Strain of Origin:  (C57BL/6 x CBA/Ca)F2
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(Ins2-CD80)3B7Flv expresses 1 gene
 
Tg(Ins2-CD80)3B7Flv expression driven by 1 gene
    The transgene contains a human CD80 antigen gene driven by the rat insulin II promoter (Ins2). (J:88250)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Disease models
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Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 5 strains available      Cell Lines: 0 lines available
Notes
Mice carrying this transgene that also are homozygous for Prkdcscid are characterized by pancreatic beta cells that express a rat insulin II promoter regulated transgene encoding the human CD80 T cell co-stimulatory molecule.
References
Original:  J:88250 Guerder S, et al., Costimulator B7-1 confers antigen-presenting-cell function to parenchymal tissue and in conjunction with tumor necrosis factor alpha leads to autoimmunity in transgenic mice. Proc Natl Acad Sci U S A. 1994 May 24;91(11):5138-42
All:  28 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory