Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Camkk2tm1Kpg
Name:	calcium/calmodulin-dependent protein kinase kinase 2, beta; targeted mutation 1, K Peter Giese
MGI ID:	MGI:2681319
Gene:	Camkk2  Location: Chr5:122869233-122917472 bp, - strand  Genetic Position: Chr5, 62.55 cM
Alliance:	Camkk2tm1Kpg page

Germline Transmission:	Earliest citation of germline transmission: J:86370
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5 was removed via cre mediated recombination of a single loxP site in intron 4 and the 3' loxP site of a floxed neo cassette in intron 5. The deletion of exon 5 results in the removal of sequence encoding part of the catalytic domain common to all CaM kinase kinase beta isoforms and putatively generates a frameshift mutation that leads to a premature stop codon. Protein was undetected in the forebrain and cerebellum of homozygous mutant mice by homologous recombination. (J:86370)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Camkk2 Mutation:	40 strains or lines available

Original:	J:86370 Peters M, et al., Loss of Ca2+/calmodulin kinase kinase beta affects the formation of some, but not all, types of hippocampus-dependent long-term memory. J Neurosci. 2003 Oct 29;23(30):9752-60
All:	5 reference(s)