Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Plcl2tm1Tta
Name:	phospholipase C-like 2; targeted mutation 1, Tadaomi Takenawa
MGI ID:	MGI:2679632
Synonyms:	PLC-L2-, PRIP-2 KO
Gene:	Plcl2  Location: Chr17:50816431-50995512 bp, + strand  Genetic Position: Chr17, 25.86 cM, cytoband C
Alliance:	Plcl2tm1Tta page

Germline Transmission:	Earliest citation of germline transmission: J:85960
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced with a cassette containing a neomycin resistance gene. The deleted exon encoded the pleckstrin homology domain, the X-Y domain, and the C2 domain. Protein was undetected in homozygous mutant mice by Western blot analysis of spleen extracts. (J:85960)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Plcl2 Mutation:	51 strains or lines available

Original:	J:85960 Takenaka K, et al., Role of phospholipase C-L2, a novel phospholipase C-like protein that lacks lipase activity, in B-cell receptor signaling. Mol Cell Biol. 2003 Oct;23(20):7329-38
All:	15 reference(s)