Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Acacbtm1Sjw
Name:	acetyl-Coenzyme A carboxylase beta; targeted mutation 1, Salih J Wakil
MGI ID:	MGI:2679547
Synonyms:	Acc2-, Acc2tm1AE
Gene:	Acacb  Location: Chr5:114284748-114388822 bp, + strand  Genetic Position: Chr5, 55.97 cM
Alliance:	Acacbtm1Sjw page

Germline Transmission:	Earliest citation of germline transmission: J:68427
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The exon encoding the biotin binding motif and flanking genomic sequence was replaced by an HPRT expression cassette by homologous recombination. Northern blot analysis on RNA derived from skeletal muscle demonstrated that no detectable transcript was expressed from this allele in homozygous mice. Western blot analysis on extracts of various tissues confirmed that no detectable protein was present in homozygous mice. (J:68427)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Acacb Mutation:	109 strains or lines available

Original:	J:68427 Abu-Elheiga L, et al., Continuous fatty acid oxidation and reduced fat storage in mice lacking acetyl-CoA carboxylase 2. Science. 2001 Mar 30;291(5513):2613-6
All:	9 reference(s)