Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Thratm1Brnt
Name:	thyroid hormone receptor alpha; targeted mutation 1, Gregory A Brent
MGI ID:	MGI:2679056
Synonyms:	P398H, TRalpha P398H
Gene:	Thra  Location: Chr11:98631539-98659832 bp, + strand  Genetic Position: Chr11, 62.58 cM, cytoband D-E
Alliance:	Thratm1Brnt page

Germline Transmission:	Earliest citation of germline transmission: J:85803
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Dominant negative) Mutation:    Single point mutation   Mutation details: A cytosine to adnenosine transversion point mutation was engineered in exon 9, using a "hit and run" strategey, affecting a proline to histidine missense mutation at codon 398 (P398H). The mutation is dominant-negative. (J:86164)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Thra Mutation:	39 strains or lines available

Original:	J:85803 Liu YY, et al., A thyroid hormone receptor alpha gene mutation (P398H) is associated with visceral adiposity and impaired catecholamine-stimulated lipolysis in mice. J Biol Chem. 2003 Oct 3;278(40):38913-20
All:	3 reference(s)