Summary | Mutation origin | Mutation description | Expression | Phenotypes | Tumor data | Find Mice (IMSR) | References

Symbol:	Hif1atm1Stom
Name:	hypoxia inducible factor 1, alpha subunit; targeted mutation 1, Shuhei Tomita
MGI ID:	MGI:2677892
Synonyms:	Hif-1alphaF, Hif-1alphaflox
Gene:	Hif1a  Location: Chr12:73948149-73994304 bp, + strand  Genetic Position: Chr12, 31.99 cM
Alliance:	Hif1atm1Stom page

Germline Transmission:	Earliest citation of germline transmission: J:85763
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exons 13, 14, and 15 were flanked by single loxP sites. The floxed region encodes the C-terminal transactivation domain that is involved in response to hypoxia, Cri2 recruitment, and efficient nuclear localization. (J:85763)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

List all tumor models in MMHCdb carrying Hif1atm1Stom

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Hif1a Mutation:	48 strains or lines available

Original:	J:85763 Tomita S, et al., Defective brain development in mice lacking the Hif-1alpha gene in neural cells. Mol Cell Biol. 2003 Oct;23(19):6739-49
All:	40 reference(s)