Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Stat3tm1Desi
Name:	signal transducer and activator of transcription 3; targeted mutation 1, Stephen Desiderio
MGI ID:	MGI:2673309
Synonyms:	Stat3Beta-
Gene:	Stat3  Location: Chr11:100777632-100830447 bp, - strand  Genetic Position: Chr11, 63.82 cM
Alliance:	Stat3tm1Desi page

Germline Transmission:	Earliest citation of germline transmission: J:77307
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Nucleotide substitutions   Mutation details: Exon 23 was replaced with modified sequence in which nucleotide susbtitutions within 3 polypyrimidine tracts and an AG dinucleotide were made in order to disrupt an internal splice acceptor site specific to the beta isoform. Transcript encoding the beta isoform was undetected by RT-PCR analysis of homozygous mutant hepatic mRNA, while wild-type levels of transcript encoding the alpha isoform were observed. Analysis of MEFs reiterated these findings at the protein level. (J:77307)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Stat3 Mutation:	70 strains or lines available

Original:	J:77307 Yoo JY, et al., Specific ablation of Stat3beta distorts the pattern of Stat3-responsive gene expression and impairs recovery from endotoxic shock. Cell. 2002 Feb 8;108(3):331-44
All:	4 reference(s)