Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Adam15tm1Bbl
Name:	ADAM metallopeptidase domain 15; targeted mutation 1, Carl P Blobel
MGI ID:	MGI:2672997
Synonyms:	adam15-
Gene:	Adam15  Location: Chr3:89246947-89257589 bp, - strand  Genetic Position: Chr3, 39.07 cM
Alliance:	Adam15tm1Bbl page

Germline Transmission:	Earliest citation of germline transmission: J:84800
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1, which encodes the initiator methionine and the first 27 amino acids, was replaced with a neo cassette inserted by homologous recombination. Protein was undetected in homozygous mutant mice by either Western blot analysis of heart extracts or immunohistochemical staining of sections of the descending aorta and subcardinal vein. (J:84800)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	3 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Adam15 Mutation:	36 strains or lines available

Original:	J:84800 Horiuchi K, et al., Potential role for ADAM15 in pathological neovascularization in mice. Mol Cell Biol. 2003 Aug;23(16):5614-24
All:	12 reference(s)