Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nanos1tm1Ysa
Name:	nanos C2HC-type zinc finger 1; targeted mutation 1, Yumiko Saga
MGI ID:	MGI:2671008
Synonyms:	nanos1-
Gene:	Nanos1  Location: Chr19:60744425-60748352 bp, + strand  Genetic Position: Chr19, 56.52 cM
Alliance:	Nanos1tm1Ysa page

Germline Transmission:	Earliest citation of germline transmission: J:84414
Parent Cell Line:	TT2 (ES Cell)
Strain of Origin:	(C57BL/6NCrlj x CBA/JNCrlj)F1

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: A LacZ and a PGK-neomycin cassette were inserted just before the translation start site of the only gene exon. Chimeric mice were crossed with CAG-Cre mice to excise the neo cassette. Progeny of this cross were examined by PCR to check for mRNA expression. Expression was absent in tissues of homozygotes. (J:84414)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

59 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nanos1 Mutation:	12 strains or lines available

Original:	J:84414 Haraguchi S, et al., nanos1: a mouse nanos gene expressed in the central nervous system is dispensable for normal development. Mech Dev. 2003 Jun;120(6):721-31
All:	1 reference(s)