Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Rln1tm1Wint
Name:	relaxin 1; targeted mutation 1, Marelyn Wintour
MGI ID:	MGI:2668458
Synonyms:	Rln-, rlx-
Gene:	Rln1  Location: Chr19:29309155-29312070 bp, - strand  Genetic Position: Chr19, 23.83 cM
Alliance:	Rln1tm1Wint page

Germline Transmission:	Earliest citation of germline transmission: J:52024
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 750 bp fragment was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded 90 carboxy terminal amino acids of the 103 amino acids that make up the C peptide and 17 amino terminal amino acids of the 25 amino acids that comprise the A chain. Northern blot analysis of ovarian RNA indicated an absence of normal transcript in homozygous mutant females. (J:52024)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	26 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Rln1 Mutation:	17 strains or lines available

Original:	J:52024 Zhao L, et al., Mice without a functional relaxin gene are unable to deliver milk to their pups. Endocrinology. 1999 Jan;140(1):445-53
All:	27 reference(s)