Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Ryktm1Stac
Name:	receptor-like tyrosine kinase; targeted mutation 1, Steven A Stacker
MGI ID:	MGI:2667542
Synonyms:	Ryk-
Gene:	Ryk  Location: Chr9:102712119-102785506 bp, + strand  Genetic Position: Chr9, 54.72 cM
Alliance:	Ryktm1Stac page

Germline Transmission:	Earliest citation of germline transmission: J:84392
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: A 14.5 kb genomic fragment was replaced with an IRES-betageo-pA cassette that was expected to join the endogenous exon 2 splice acceptor site. The deleted region included exons 2 through 6, which encode 95% of the extracellular domain and all of the transmembrane domain. RT-PCR and Western blot analyses indicated the absence of transcript and protein in homozygous mutant mice. (J:84392)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	36 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Ryk Mutation:	29 strains or lines available

Original:	J:84392 Halford MM, et al., Ryk-deficient mice exhibit craniofacial defects associated with perturbed Eph receptor crosstalk. Nat Genet. 2000 Aug;25(4):414-8
All:	16 reference(s)