Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol: Slc27a4tm1Wsr Name: solute carrier family 27 (fatty acid transporter), member 4; targeted mutation 1, Wolfgang Stremmel MGI ID: MGI:2667328 Synonyms: Fatp4-, Fatp4flox, Fatp4-K Gene: Slc27a4  Location: Chr2:29692646-29707534 bp, + strand  Genetic Position: Chr2, 20.64 cM, cytoband B Alliance: Slc27a4tm1Wsr page

Abnormal appearance of Slc27a4tm1Wsr/Slc27a4tm1Wsr mice, with facial dysmorphia, skin abnormalities and a rigid torso Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:84096
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: A 7172 bp insert containing a splice acceptor, IRES, lacZ reporter gene and a neomycin resistance gene, all flanked by two FLP recombinase target sites was placed in intron 2 at the same time that loxP sites were inserted on either side of exon 3. Northern blot analysis established the absence of mRNA transcripts from the targeted gene and Western blots demonstrated the absence of protein products. (J:84096)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

10 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Slc27a4 Mutation:	36 strains or lines available

Original:	J:84096 Herrmann T, et al., Mice with targeted disruption of the fatty acid transport protein 4 (Fatp 4, Slc27a4) gene show features of lethal restrictive dermopathy. J Cell Biol. 2003 Jun 23;161(6):1105-15
All:	7 reference(s)