Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Nck1tm1Paw Name: non-catalytic region of tyrosine kinase adaptor protein 1; targeted mutation 1, Tony Pawson MGI ID: MGI:2667151 Synonyms: Nck1-, Nck1IRES-lacZ Gene: Nck1  Location: Chr9:100376047-100428187 bp, - strand  Genetic Position: Chr9, 52.69 cM Alliance: Nck1tm1Paw page

Reduced inflammation in aortic roots obtained from tamoxifen-treated, high-fat diet fed Apoetm1Unc/Apoetm1Unc Tg(Cdh5-cre/ERT2)1Rha/0 Nck1tm1Paw/Nck1tm1Paw Nck2tm3Paw/Nck2tm3Paw mice. Show the 4 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:83956
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: An IRES-beta-galactosidase cassette was inserted into the first coding exon 29 nucleotides downstream from the start codon. This disrupts one of three SH3 domains. (J:83956)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

67 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 2 strains available      Cell Lines: 0 lines available
Carrying any Nck1 Mutation:	40 strains or lines available

Original:	J:83956 Bladt F, et al., The murine Nck SH2/SH3 adaptors are important for the development of mesoderm-derived embryonic structures and for regulating the cellular actin network. Mol Cell Biol. 2003 Jul;23(13):4586-97
All:	23 reference(s)