Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tmod2tm1Hzo
Name:	tropomodulin 2; targeted mutation 1, Huda Y Zoghbi
MGI ID:	MGI:2664500
Synonyms:	A12, Tmod2lacZ-
Gene:	Tmod2  Location: Chr9:75472903-75518607 bp, - strand  Genetic Position: Chr9, 42.31 cM
Alliance:	Tmod2tm1Hzo page

Germline Transmission:	Earliest citation of germline transmission: J:83752
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 1 was deleted and replaced with an in-frame lacZ-PGK-neo cassette via homologous recombination. Absence of gene expression was confirmed by Western blot analysis of brain proteins from homozygous mutant animals. (J:83752)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

37 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tmod2 Mutation:	16 strains or lines available

Original:	J:83752 Cox PR, et al., Mice lacking Tropomodulin-2 show enhanced long-term potentiation, hyperactivity, and deficits in learning and memory. Mol Cell Neurosci. 2003 May;23(1):1-12
All:	1 reference(s)