Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Mbd1tm1Fhg
Name:	methyl-CpG binding domain protein 1; targeted mutation 1, Fred H Gage
MGI ID:	MGI:2664084
Synonyms:	MBD1-, Mbd1KO
Gene:	Mbd1  Location: Chr18:74400676-74415803 bp, + strand  Genetic Position: Chr18, 50.7 cM
Alliance:	Mbd1tm1Fhg page

Germline Transmission:	Earliest citation of germline transmission: J:83613
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: Exons 2 through 10 were replaced by homologous recombination of a targeting vector containing lacZ and neo. The deleted region encoded the MBD1, CXXC1, CXXC2, and CXXC3 domains. Transcript was undetected in homozygous mutant brain tissue by Northern blot analysis and in situ hybridization. (J:83613)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Mbd1 Mutation:	33 strains or lines available

Original:	J:83613 Zhao X, et al., Mice lacking methyl-CpG binding protein 1 have deficits in adult neurogenesis and hippocampal function. Proc Natl Acad Sci U S A. 2003 May 27;100(11):6777-82
All:	8 reference(s)