Analysis Tools
neoplasm
|
• incidence of 7,12-dimethylbenzanthracene (DMBA)-induced skin tumors is enhanced, however mutants do not develop spontaneous tumors by 1 year of age
• onset of DMBA-induced skin tumors occurs earlier than in wild-type
|
cellular
|
• mouse embryonic fibroblasts (MEFs) fail to arrest at G1 at low ionizing radiation (IR) doses but behave normally at higher doses
• mutants exposed to IR radiation exhibit a shorter duration of the G2/M checkpoint in the epidermis than wild-type, with mitosis resuming by 24 hours post-IR
• gamma-irradiated thymic cells show a partial defect in G1/S-phase checkpoint, with a milder G1 arrest than observed in Trp53 and Atm mutants
|
|
• cells from thymus, CNS, hair follicles, and fibroblasts are resistant to gamma irradiation-induced apoptosis
• unlike wild-type epidermal cells that show a reduction in proliferation 24 hours post IR irradiation, mutant epidermal cells exhibit no reduction in proliferation
|
homeostasis/metabolism
|
• incidence of 7,12-dimethylbenzanthracene (DMBA)-induced skin tumors is enhanced, however mutants do not develop spontaneous tumors by 1 year of age
• onset of DMBA-induced skin tumors occurs earlier than in wild-type
|
