Summary | Mutation origin | Mutation description | Find Mice (IMSR) | References

Symbol:	Grk6tm1Mca
Name:	G protein-coupled receptor kinase 6; targeted mutation 1, Marc G Caron
MGI ID:	MGI:2661088
Gene:	Grk6  Location: Chr13:55592885-55608740 bp, + strand  Genetic Position: Chr13, 30.06 cM, cytoband B1-3
Alliance:	Grk6tm1Mca page

Germline Transmission:	Earliest citation of germline transmission: J:83191
Parent Cell Line:	AK7 (ES Cell)
Strain of Origin:	129S4/SvJaeSor

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: Exons 3 through 9 were flanked by an upstream floxed neomycin resistance cassette and a downstream single loxP site. Cre-mediated recombination in vivo under the control of a CMV promoter removed the neo cassette in the germline, leaving exons 3-9 flanked by loxP sites. (J:83191)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Grk6 Mutation:	36 strains or lines available

Original:	J:83191 Gainetdinov RR, et al., Dopaminergic supersensitivity in G protein-coupled receptor kinase 6-deficient mice. Neuron. 2003 Apr 24;38(2):291-303
All:	3 reference(s)