Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Atp2a1tm1Dhm Name: ATPase, Ca++ transporting, cardiac muscle, fast twitch 1; targeted mutation 1, David H MacLennon MGI ID: MGI:2656945 Synonyms: SERCA1-, SERCA1-null Gene: Atp2a1  Location: Chr7:126045032-126062245 bp, - strand  Genetic Position: Chr7, 69.04 cM Alliance: Atp2a1tm1Dhm page

Atp2a1tm1Dhm/Atp2a1tm1Dhm newborns are cyanotic Show the 3 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:82947
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 1-4 with a PGK-neo cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Western blot and RT-PCR analysis. (J:82947)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Atp2a1 Mutation:	44 strains or lines available

Original:	J:82947 Pan Y, et al., Targeted disruption of the ATP2A1 gene encoding the sarco(endo)plasmic reticulum Ca2+ ATPase isoform 1 (SERCA1) impairs diaphragm function and is lethal in neonatal mice. J Biol Chem. 2003 Apr 11;278(15):13367-75
All:	1 reference(s)