Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Amottm1Bhr
Name:	angiomotin; targeted mutation 1, Richard R Behringer
MGI ID:	MGI:2656627
Synonyms:	Xamot
Gene:	Amot  Location: ChrX:144229420-144288145 bp, - strand  Genetic Position: ChrX, 66.72 cM
Alliance:	Amottm1Bhr page

Germline Transmission:	Earliest citation of germline transmission: J:82844
Parent Cell Line:	AB1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the splice acceptor site of the second exon with a PGK-neo cassette via homologous recombination. RT-PCR sequence analysis showed the mutant allele contains a frameshift and premature stop codon, therefore no functional protein product should be translated. (J:82844)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

8 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Amot Mutation:	11 strains or lines available

Original:	J:82844 Shimono A, et al., Angiomotin Regulates Visceral Endoderm Movements during Mouse Embryogenesis. Curr Biol. 2003 Apr 1;13(7):613-7
All:	5 reference(s)