Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Myh11tm1Bdr
Name:	myosin, heavy polypeptide 11, smooth muscle; targeted mutation 1, Michael Bader
MGI ID:	MGI:2656492
Synonyms:	SM-MHC -
Gene:	Myh11  Location: Chr16:14012392-14109227 bp, - strand  Genetic Position: Chr16, 9.71 cM
Alliance:	Myh11tm1Bdr page

Germline Transmission:	Earliest citation of germline transmission: J:82859
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 5b was replaced with a neomycin selection cassette inserted by homologous recombination. Neither transcript nor protein were detected in homozygous mutant mice by Northern or Western blot analyses. Expression of non-muscle myosin heavy chain is not affected. (J:82859)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Myh11 Mutation:	93 strains or lines available

Original:	J:82859 Morano I, et al., Smooth-muscle contraction without smooth-muscle myosin. Nat Cell Biol. 2000 Jun;2(6):371-5
All:	3 reference(s)