Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Ndntm2Stw
Name:	necdin, MAGE family member; targeted mutation 2, Colin L Stewart
MGI ID:	MGI:2653048
Synonyms:	Ndn-null
Gene:	Ndn  Location: Chr7:61998025-61999676 bp, + strand  Genetic Position: Chr7, 34.36 cM, cytoband C
Alliance:	Ndntm2Stw page

Germline Transmission:	Earliest citation of germline transmission: J:57890
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The floxed neo cassette was excised from Ndntm1Stw via in vivo cre mediated recombination. Sequence encoding lacZ was left in place of protein coding sequence downstream of the endogenous codon 31. (J:57890)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	91 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Ndn Mutation:	18 strains or lines available

Original:	J:57890 Gerard M, et al., Disruption of the mouse necdin gene results in early post-natal lethality [see comments]. Nat Genet. 1999 Oct;23(2):199-202
All:	11 reference(s)