Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Selenoptm1Kohr
Name:	selenoprotein P; targeted mutation 1, Josef Kohrle
MGI ID:	MGI:2652747
Synonyms:	SePP-, SEPPKO
Gene:	Selenop  Location: Chr15:3300249-3309992 bp, + strand  Genetic Position: Chr15, 1.84 cM
Alliance:	Selenoptm1Kohr page

Germline Transmission:	Earliest citation of germline transmission: J:82244
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout, Reporter) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of the coding exons with an in-frame exon2-lacZ fusion construct and a neomycin resistance gene via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of liver and brain RNA. (J:82244)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Selenop Mutation:	22 strains or lines available

Original:	J:82244 Schomburg L, et al., Gene disruption discloses role of selenoprotein P in selenium delivery to target tissues. Biochem J. 2003 Mar 1;370(Pt 2):397-402
All:	5 reference(s)