Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nfictm1Rmg
Name:	nuclear factor I/C; targeted mutation 1, Richard M Gronostajski
MGI ID:	MGI:2450153
Synonyms:	Nfic-, NFI-C-
Gene:	Nfic  Location: Chr10:81232025-81267753 bp, - strand  Genetic Position: Chr10, 39.72 cM, cytoband C1
Alliance:	Nfictm1Rmg page

Germline Transmission:	Earliest citation of germline transmission: J:81645
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 1.3 kb fragment encompassing exon 2 and flanking intronic sequence was replaced with a neomycin selection cassette inserted by homologous recombination. The deleted region encoded both the DNA-binding and dimerization domains. An aberrant transcript resulting from a splice of exon 1 to exon 3 was identified by RT-PCR analysis of homozygous mutant liver and brain tissues. Sequence analysis indicated that the mutant transcript is out of frame and terminates in exon 3, encoding a polypeptide comprised of 31 residues. (J:81645)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	9 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nfic Mutation:	35 strains or lines available

Original:	J:81645 Steele-Perkins G, et al., Essential role for NFI-C/CTF transcription-replication factor in tooth root development. Mol Cell Biol. 2003 Feb;23(3):1075-84
All:	12 reference(s)