Apctm3Mmt
Targeted Allele Detail
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Symbol: |
Apctm3Mmt |
Name: |
APC, WNT signaling pathway regulator; targeted mutation 3, Makoto M Taketo |
MGI ID: |
MGI:2449944 |
Synonyms: |
ApcneoR |
Gene: |
Apc Location: Chr18:34353977-34455605 bp, + strand Genetic Position: Chr18, 18.53 cM
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Alliance: |
Apctm3Mmt page
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Germline Transmission: |
Earliest citation of germline transmission:
J:81402
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Parent Cell Line: |
RW-4 (ES Cell)
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Strain of Origin: |
129X1/SvJ
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Allele Type: |
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Targeted (Conditional ready, Hypomorph) |
Mutation: |
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Insertion
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Mutation details: LoxP sites flanking exons 11-13 were introduced and a neomycin resistance gene was inserted downstream of exon 13 in the direction opposite of transcription. RT-PCR analysis of heterozygous and homozygous mutant animals showed reduced gene expression at approximately 55% and 20% that of wild-type, respectively. This is a hypomorphic allele.
(J:81402)
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View phenotypes and curated references for all genotypes (concatenated display).
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Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Carrying any Apc Mutation: |
154 strains or lines available
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Original: |
J:81402 Ishikawa TO, et al., Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol. 2003 Jan 15;253(2):230-46 |
All: |
3 reference(s) |
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