Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Apctm2Mmt
Name:	APC, WNT signaling pathway regulator; targeted mutation 2, Makoto M Taketo
MGI ID:	MGI:2449941
Synonyms:	ApclacZ
Gene:	Apc  Location: Chr18:34353977-34455605 bp, + strand  Genetic Position: Chr18, 18.53 cM
Alliance:	Apctm2Mmt page

Germline Transmission:	Earliest citation of germline transmission: J:81402
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout, Reporter) Mutation:    Insertion   Mutation details: The gene was disrupted by insertion of a lacZ-PGK-neo cassette into codon 716 of exon 15. LacZ reporter activity was observed by whole mount in situ staining at embryonic day E6.5. (J:81402)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	12 assay results
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Apc Mutation:	154 strains or lines available

Original:	J:81402 Ishikawa TO, et al., Requirement for tumor suppressor Apc in the morphogenesis of anterior and ventral mouse embryo. Dev Biol. 2003 Jan 15;253(2):230-46
All:	1 reference(s)