Tg(LCKprBCL2)36Sjk
Transgene Detail
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| Symbol: |
Tg(LCKprBCL2)36Sjk |
| Name: |
transgene insertion 36, Stanley J Korsmeyer |
| MGI ID: |
MGI:2447592 |
| Synonyms: |
Lck-Bcl-2, Lck-BCL2, lckpr-bcl-2, prLck.hbcl-2 |
| Transgene: |
Tg(LCKprBCL2)36Sjk Location: unknown
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| Alliance: |
Tg(LCKprBCL2)36Sjk page
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| Strain of Origin: |
Not Specified
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| Transgene Type: |
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Transgenic (Humanized sequence, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(LCKprBCL2)36Sjk expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
BCL2 (596) |
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Mutation details: The transgene consists of 0.75 kb of Lck proximal promoter sequences (active in lymphoid tissues) and 3.2 kb of human BCL2 cDNA. Introns, exons, and polyadenylation sequences from the human growth hormone gene consitutes the 3' untranslated region of the construct. Transgene expression in the thymus, lymph nodes, and spleen was verified by Western blot analysis and immunohistochemistry. Seven transgenic lines were established with lines 7, 17, and 36 expressing the transgene at high levels.
(J:11548)
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View phenotypes and curated references for all genotypes (concatenated display).
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 1 strain available
Cell Lines: 0 lines available
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| Original: |
J:11548 Sentman CL, et al., bcl-2 inhibits multiple forms of apoptosis but not negative selection in thymocytes. Cell. 1991 Nov 29;67(5):879-88 |
| All: |
54 reference(s) |
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Analysis Tools
