Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Tbx6tm1Pa
Name:	T-box 6; targeted mutation 1, Virginia Papaioannou
MGI ID:	MGI:2447721
Gene:	Tbx6  Location: Chr7:126380655-126384720 bp, + strand  Genetic Position: Chr7, 69.25 cM
Alliance:	Tbx6tm1Pa page

Germline Transmission:	Earliest citation of germline transmission: J:80954
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encompassing all of exons 1 and 2 and a portion of exon 3 was replaced by a neo cassette inserted by homologous recombination. The deleted region encoded the initiator methionine and the DNA-binding domain of the T-box. (J:80954)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	55 assay results
In Structures Affected by this Mutation:	7 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Tbx6 Mutation:	17 strains or lines available

Original:	J:80954 Chapman DL, et al., Three neural tubes in mouse embryos with mutations in the T-box gene Tbx6. Nature. 1998 Feb 12;391(6668):695-7
All:	13 reference(s)