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Tg(LCKprBCL2L1)12Sjk
Transgene Detail
Summary
Symbol: Tg(LCKprBCL2L1)12Sjk
Name: transgene insertion 12, Stanley J Korsmeyer
MGI ID: MGI:2447593
Synonyms: Bcl-xL, Bcl-xLTg, Bcl-xL-Tg, lckpr-bcl-xL
Transgene: Tg(LCKprBCL2L1)12Sjk  Location: unknown  
Alliance: Tg(LCKprBCL2L1)12Sjk page
Transgene
origin
Strain of Origin:  Not Specified
Transgene
description
Transgene Type:    Transgenic (Humanized sequence, Inserted expressed sequence)
Mutation:    Insertion
 
Tg(LCKprBCL2L1)12Sjk expresses 1 gene
 
Mutation detailsThe transgene consists of 0.75 kb of Lck proximal promoter sequences and 0.8 kb of human BCL2L1 cDNA. Introns, exons, and polyadenylation sequences from the human growth hormone gene consitutes the 3' untranslated region of the construct. The Lck promoter was used to drive transgene expression in lymphoid tissues. Transgene expression in the thymus and spleen was verified by Western blot analysis and flow cytometry. (J:78583)
Phenotypes
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View phenotypes and curated references for all genotypes (concatenated display).
Find Mice (IMSR)
Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:  Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Notes
Transgenic lines 12 and 24, which expressed high amounts of the transgene, were established. Most of the analysis was performed using line 12 and confirmed with line 24.
References
Original:  J:78583 Chao DT, et al., Bcl-XL and Bcl-2 repress a common pathway of cell death. J Exp Med. 1995 Sep 1;182(3):821-8
All:  35 reference(s)

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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last database update
03/19/2024
MGI 6.23
The Jackson Laboratory