Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Il21rtm1Wjl Name: interleukin 21 receptor; targeted mutation 1, Warren J Leonard MGI ID: MGI:2446509 Synonyms: IL-21R- Gene: Il21r  Location: Chr7:125202601-125232742 bp, + strand  Genetic Position: Chr7, 68.98 cM, cytoband F4 Alliance: Il21rtm1Wjl page

IL-21R deficiency prevents renal disease and mortality characteristic of BXSB-Yaa mice Show the 2 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:80474
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The endogenous locus was disrupted by the insertion of a neomycin selection cassette. Sequence encoding the majority of the signal peptide through the transmembrane domain was replaced by neo, resulting in a frameshift mutation affecting sequence encoding the cytoplasmic domain. Transcript was undetected by RT-PCR analysis of thymocytes obtained from homozygous mutant mice. (J:80474, J:95221)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 6 strains available      Cell Lines: 0 lines available
Carrying any Il21r Mutation:	41 strains or lines available

Original:	J:80474 Ozaki K, et al., A critical role for IL-21 in regulating immunoglobulin production. Science. 2002 Nov 22;298(5598):1630-4
All:	68 reference(s)