Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Icostm1Mak
Name:	inducible T cell co-stimulator; targeted mutation 1, Tak Mak
MGI ID:	MGI:2445839
Synonyms:	ICOS-
Gene:	Icos  Location: Chr1:61017086-61039479 bp, + strand  Genetic Position: Chr1, 30.6 cM
Alliance:	Icostm1Mak page

Germline Transmission:	Earliest citation of germline transmission: J:66702
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of exon 2 and all of exons 3 and 4 were replaced by a neomycin selection cassette inserted by homologous recombination. The deleted region encoded the putative Icosl binding site, the transmembrane domain, and a portion of the intracellular domain including the YMFM motif that potentially binds lipid phosphotidylinositol 3 kinase. Flow cytometric analysis indicated an absence of protein on the surface of activated T cells obtained from homozygous mutant mice. (J:66702)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Icos Mutation:	35 strains or lines available

Original:	J:66702 Tafuri A, et al., ICOS is essential for effective T-helper-cell responses. Nature. 2001 Jan 4;409(6816):105-9
All:	51 reference(s)