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Dlec1 Gene Detail
Summary
  • Symbol
    Dlec1
  • Name
    deleted in lung and esophageal cancer 1
  • Synonyms
    D630005C06Rik
  • Feature Type
    protein coding gene
  • IDs
    MGI:2443671
    NCBI Gene: 320256
  • Alliance
    gene page
  • Transcription Start Sites
    4 TSS
Location &
Maps
more
  • Sequence Map
    Chr9:118931546-118977314 bp, + strand
    From Ensembl annotation of GRCm39
  • View this region in JBrowse
  • Genome Browsers
    Ensembl | UCSC | NCBI
  • Genetic Map
    Chromosome 9, 71.32 cM
  • Mapping Data
    1 experiment
Strain
Comparison
more
  • SNPs within 2kb
    388 from dbSNP Build 142
  • Strain Annotations
    18
For selected strains:
Strain Gene Model ID Feature Type Coordinates Select Strains
C57BL/6J MGI_C57BL6J_2443671
 protein coding gene Chr9:118927720-118977314 (+)
129S1/SvImJ MGP_129S1SvImJ_G0035411
 protein coding gene Chr9:121816017-121861906 (+)
A/J MGP_AJ_G0035391
 protein coding gene Chr9:117319010-117364763 (+)
AKR/J MGP_AKRJ_G0035324
 protein coding gene Chr9:120355581-120403340 (+)
BALB/cJ MGP_BALBcJ_G0035387
 protein coding gene Chr9:117184984-117232975 (+)
C3H/HeJ MGP_C3HHeJ_G0035095
 protein coding gene Chr9:120824903-120871820 (+)
C57BL/6NJ MGP_C57BL6NJ_G0035910
 protein coding gene Chr9:125162777-125209612 (+)
CAROLI/EiJ MGP_CAROLIEiJ_G0032793
 protein coding gene Chr9:114512459-114556581 (+)
CAST/EiJ MGP_CASTEiJ_G0034399
 protein coding gene Chr9:120787663-120841005 (+)
CBA/J MGP_CBAJ_G0035062
 protein coding gene Chr9:129869211-129918442 (+)
DBA/2J MGP_DBA2J_G0035221
 protein coding gene Chr9:116755687-116802305 (+)
FVB/NJ MGP_FVBNJ_G0035168
 protein coding gene Chr9:115600426-115647102 (+)
LP/J MGP_LPJ_G0035300
 protein coding gene Chr9:122167174-122214508 (+)
NOD/ShiLtJ MGP_NODShiLtJ_G0035209
 protein coding gene Chr9:130854638-130902245 (+)
NZO/HlLtJ MGP_NZOHlLtJ_G0035929
 protein coding gene Chr9:120744659-120791794 (+)
PWK/PhJ MGP_PWKPhJ_G0034106
 protein coding gene Chr9:117168702-117215675 (+)
SPRET/EiJ MGP_SPRETEiJ_G0033940
 protein coding gene Chr9:120856589-120905763 (+)
WSB/EiJ MGP_WSBEiJ_G0034520
 protein coding gene Chr9:120630316-120677913 (+)



Homology
more
  • Human Ortholog
    DLEC1, DLEC1 cilia and flagella associated protein
  • Vertebrate Orthologs
    3
Vertebrate Orthology Source
Alliance of Genome Resources
  • Human Ortholog
    DLEC1, DLEC1 cilia and flagella associated protein
  • Synonyms
    CFAP81, DLC1, DLC-1, F56, FAP81
  • Links
    NCBI Gene ID: 9940
    neXtProt AC: NX_Q9Y238
    UniProt: Q9Y238

  • Chr Location
    3p22.2; chr3:38039205-38124025 (+)  GRCh38
Human Diseases
more
  • Diseases
    1 with human DLEC1 associations

Human Disease Mouse Models
      
IDs
Click on a disease name to see all genes associated with that disease.

Mutations,
Alleles, and
Phenotypes
less
  • Phenotype Summary
    14 phenotypes from 3 alleles in 3 genetic backgrounds
    21 phenotype references
Phenotype Overview

adipose tissue
behavior/neurological
cardiovascular system
cellular
craniofacial
digestive/alimentary system
embryo
endocrine/exocrine glands
growth/size/body
hearing/vestibular/ear
hematopoietic system
homeostasis/metabolism
integument
immune system
limbs/digits/tail
liver/biliary system
mortality/aging
muscle
nervous system
pigmentation
renal/urinary system
reproductive system
respiratory system
skeleton
taste/olfaction
neoplasm
vision/eye

Click cells to view annotations.
Mice hmozygous for a null allele exhibit male infertility with oligozoospermia, asthenozoospermia, and abnormal sperm morphology.
Gene Ontology
(GO)
Classifications
less
  • All GO Annotations
    11
  • GO References
    6
Molecular Function

carbohydrate derivative binding
cytoskeletal protein binding
DNA binding
enzyme regulator
hydrolase
ligase
lipid binding
oxidoreductase
RNA binding
signaling receptor activity
signaling receptor binding
transcription
transferase
transporter
Biological Process

carbohydrate derivative metabolism
cell differentiation
cell population proliferation
cellular component organization
DNA-templated transcription
establishment of localization
homeostatic process
immune system process
lipid metabolic process
programmed cell death
protein metabolic process
response to stimulus
signaling
system development
Cellular Component

cell projection
cytoplasmic vesicle
cytoskeleton
cytosol
endoplasmic reticulum
endosome
extracellular region
Golgi apparatus
mitochondrion
non-membrane-bounded organelle
nucleus
organelle envelope
organelle lumen
plasma membrane
protein-containing complex
synapse
vacuole
Click cells to view annotations.
Expression
less
Expression Overview

early conceptus
embryo ectoderm
embryo endoderm
embryo mesoderm
embryo mesenchyme
extraembryonic component
alimentary system
auditory system
branchial arches
cardiovascular system
connective tissue
endocrine system
exocrine system
hemolymphoid system
integumental system
limbs
liver and biliary system
musculoskeletal system
nervous system
olfactory system
reproductive system
respiratory system
urinary system
visual system
Click cells to view annotations.


  • Assay Results
    709
  • Tissues
    2
  • cDNA Data
    11
  • Literature Summary
    1
  • Comparison Matrix
    Gene Expression + Phenotype
    • Sequences &
    Gene Models
    less
    Representative SequencesLengthStrain/SpeciesFlank
    genomic ENSMUSG00000038060 Ensembl Gene Model | MGI Sequence Detail 45769 C57BL/6J ±  kb
    transcript ENSMUST00000165231 Ensembl | MGI Sequence Detail 5263 Not Applicable  
    polypeptide ENSMUSP00000128874 Ensembl | MGI Sequence Detail 1741 Not Applicable  
    For the selected sequence
    Protein
    Information
    less
    Molecular
    Reagents
    less
    • All nucleic 11
      cDNA 11

      Microarray probesets 2
    References
    more
    • Summaries
      All 42
      Developmental Gene Expression 1
      Gene Ontology 6
      Phenotypes 21
    • Earliest
      J:12215 Chubb C, Oligotriche and quaking gene mutations. Phenotypic effects on mouse spermatogenesis and testicular steroidogenesis. J Androl. 1992 Jul-Aug;13(4):312-7
    • Latest
      J:299542 Okitsu Y, et al., Dlec1 is required for spermatogenesis and male fertility in mice. Sci Rep. 2020 Nov 3;10(1):18883
    Contributing Projects:
    Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
    Citing These Resources
    Funding Information
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    Send questions and comments to User Support.     		last database update
    04/09/2024
    MGI 6.23     		The Jackson Laboratory