Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Gktm1Wjc
Name:	glycerol kinase; targeted mutation 1, William J Craigen
MGI ID:	MGI:2429928
Gene:	Gk  Location: ChrX:84745543-84820425 bp, - strand  Genetic Position: ChrX, 39.32 cM, cytoband C-D
Alliance:	Gktm1Wjc page

Germline Transmission:	Earliest citation of germline transmission: J:43449
Parent Cell Line:	AB2.1 (ES Cell)
Strain of Origin:	129S7/SvEvBrd-Hprt1b-m2

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequence encompassing all of exons 13 and 14 as well as a portion of exon 15 was replaced with a neomycin selection cassette. mRNA was undetected by Northern blot analysis of liver tissue obtained from homozygous mutant mice. A biochemical assay showed glycerol kinase activity to be reduced by over 95% in liver, kidney, and brown fat. (J:43449)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Gk Mutation:	11 strains or lines available

Original:	J:43449 Huq AH, et al., X-linked glycerol kinase deficiency in the mouse leads to growth retardation, altered fat metabolism, autonomous glucocorticoid secretion and neonatal death. Hum Mol Genet. 1997 Oct;6(11):1803-9
All:	6 reference(s)