Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Blnktm1Achn
Name:	B cell linker; targeted mutation 1, Andrew C Chan
MGI ID:	MGI:2389137
Synonyms:	BLNK-
Gene:	Blnk  Location: Chr19:40917371-40982664 bp, - strand  Genetic Position: Chr19, 34.26 cM
Alliance:	Blnktm1Achn page

Germline Transmission:	Earliest citation of germline transmission: J:58805
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: Exon 1 was disrupted by homologous recombination of a construct containing GFP, a floxed neo gene, and a mutated start codon (ATC). While the GFP coding region was linked to its own Kozak sequence and start codon, fluorescence was undetected in splenocytes and bone marrow cells derived from heterozygous mutant mice. Immunoblot analysis on homozygote bone marrow cells failed to detect Blnk protein. (J:58805)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blnk Mutation:	76 strains or lines available

Original:	J:58805 Pappu R, et al., Requirement for B cell linker protein (BLNK) in B cell development. Science. 1999 Dec 3;286(5446):1949-54
All:	10 reference(s)