Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Art2btm1Fkn
Name:	ADP-ribosyltransferase 2b; targeted mutation 1, Friedrich Koch-Nolte
MGI ID:	MGI:2388827
Synonyms:	ART2.2-
Gene:	Art2b  Location: Chr7:101226177-101234807 bp, - strand  Genetic Position: Chr7, 54.61 cM
Alliance:	Art2btm1Fkn page

Germline Transmission:	Earliest citation of germline transmission: J:79607
Parent Cell Line:	J1 (ES Cell)
Strain of Origin:	129S4/SvJae

Allele Type:    Targeted (Null/knockout) Mutation:    Insertion   Mutation details: The coding region was disrupted by a hygromycin selection cassette inserted by homologous recombination. This construct was used to transfect mice in which the Art2atm1Fkn allele had already been created Transcript was undetected in homozygous mutant mice by RT-PCR analysis of T cells isolated from lymph nodes. FACS analysis of thymocytes and lymphocytes indicated a lack of protein expression on the cell surface. (J:79607)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 3 strains available      Cell Lines: 0 lines available
Carrying any Art2b Mutation:	23 strains or lines available

Original:	J:79607 Ohlrogge W, et al., Generation and characterization of ecto-ADP-ribosyltransferase ART2.1/ART2.2-deficient mice. Mol Cell Biol. 2002 Nov;22(21):7535-42
All:	13 reference(s)