Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Foxg1tm1(tTA)Lai
Name:	forkhead box G1; targeted mutation 1, Eseng Lai
MGI ID:	MGI:2388671
Synonyms:	BF1(-tTA), Foxg1tTA
Gene:	Foxg1  Location: Chr12:49429666-49433650 bp, + strand  Genetic Position: Chr12, 21.78 cM
Alliance:	Foxg1tm1(tTA)Lai page

Germline Transmission:	Earliest citation of germline transmission: J:78115
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Transactivator) Mutations:    Insertion, Intragenic deletion   Mutation details: Most of the coding region was replaced with a tetracycline transactivator (tTA) gene and neomycin cassette. The tTA sequence was fused in-frame following the first 13 codons of the gene. In situ hybridization analysis of E13.5 mutant embryos demonstrates that tTA expression closely matches that of Foxg1 in the telencephalon and olfactory epithelium. (J:78115)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:

4 assay results

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Foxg1 Mutation:	28 strains or lines available

Original:	J:78115 Hanashima C, et al., Brain factor-1 controls the proliferation and differentiation of neocortical progenitor cells through independent mechanisms. J Neurosci. 2002 Aug 1;22(15):6526-36
All:	21 reference(s)