Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | References

Symbol:	Syt1tm5Sud
Name:	synaptotagmin I; targeted mutation 5, Thomas C Sudhof
MGI ID:	MGI:2388629
Synonyms:	D232N
Gene:	Syt1  Location: Chr10:108333511-108846843 bp, - strand  Genetic Position: Chr10, 56.52 cM
Alliance:	Syt1tm5Sud page

Germline Transmission:	Earliest citation of germline transmission: J:79208
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Hypomorph, Inserted expressed sequence) Mutation:    Disruption caused by insertion of vector   Mutation details: An aspartate to asparagine missense mutation (D232N) was introduced into the C2A domain via homologous recombination. Western blot of brain homogenates from homozygous mutant animals verified the presence of protein expression. (J:79208)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Syt1 Mutation:	39 strains or lines available

Original:	J:79208 Fernandez-Chacon R, et al., Structure/function analysis of Ca2+ binding to the C2A domain of synaptotagmin 1. J Neurosci. 2002 Oct 1;22(19):8438-46
All:	1 reference(s)