Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Scd1tm1Ntam
Name:	stearoyl-Coenzyme A desaturase 1; targeted mutation 1, James M Ntambi
MGI ID:	MGI:2388371
Synonyms:	SCD1-
Gene:	Scd1  Location: Chr19:44382889-44396148 bp, - strand  Genetic Position: Chr19, 37.98 cM
Alliance:	Scd1tm1Ntam page

Germline Transmission:	Earliest citation of germline transmission: J:71350
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region of the gene (exons 1-6) was replaced with a neomycin resistance cassette via homologous recombination. Absence of gene expression in homozygous mutant animals was confirmed by Northern blot analysis of various tissue samples and by Western blot analysis of liver protein extracts. Enzyme activity was also undetectable in liver extracts from homozygous animals. (J:71350)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	4 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Scd1 Mutation:	24 strains or lines available

Original:	J:71350 Miyazaki M, et al., Targeted disruption of stearoyl-CoA desaturase1 gene in mice causes atrophy of sebaceous and meibomian glands and depletion of wax esters in the eyelid. J Nutr. 2001 Sep;131(9):2260-8
All:	41 reference(s)