Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Vax2tm1Grl
Name:	ventral anterior homeobox 2; targeted mutation 1, Greg Lemke
MGI ID:	MGI:2388160
Synonyms:	Vax2-
Gene:	Vax2  Location: Chr6:83688246-83715295 bp, + strand  Genetic Position: Chr6, 35.94 cM
Alliance:	Vax2tm1Grl page

Germline Transmission:	Earliest citation of germline transmission: J:74240
Parent Cell Line:	W9.5/W95 (ES Cell)
Strain of Origin:	129S1/Sv-Oca2+ Tyr+ Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Exon 2 was replaced by a neo cassette inserted by homologous recombination. RT-PCR analysis identified shortened transcript in homozygous mutant mice, lacking the targeted region, which encoded the first two alpha helices (residues 83 through 145) of the homeodomain. A loss of immunoreactivity was observed in the homozygous mutant retina. (J:74240)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	2 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Vax2 Mutation:	15 strains or lines available

Original:	J:74240 Mui SH, et al., The homeodomain protein Vax2 patterns the dorsoventral and nasotemporal axes of the eye. Development. 2002 Feb;129(3):797-804
All:	4 reference(s)