Tg(Fabpl-RAC1-T17N)1Jig
Transgene Detail
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| Symbol: |
Tg(Fabpl-RAC1-T17N)1Jig |
| Name: |
transgene insertion 1, Jeffrey I Gordon |
| MGI ID: |
MGI:2383956 |
| Synonyms: |
Rac1Asn17 |
| Transgene: |
Tg(Fabpl-RAC1-T17N)1Jig Location: unknown
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| Alliance: |
Tg(Fabpl-RAC1-T17N)1Jig page
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| Mouse Generated: |
Earliest citation of chimera generation:
J:62539
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| Parent Cell Line: |
D3 (ES Cell)
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| Strain of Origin: |
129S2/SvPas
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| Transgene Type: |
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Transgenic (Dominant negative, Inserted expressed sequence) |
| Mutation: |
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Insertion
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Tg(Fabpl-RAC1-T17N)1Jig expresses
1 gene
Transgene expresses:
| Organism |
Expressed Gene |
Homolog in Mouse |
Note |
| human |
RAC1 (5879) |
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expresses a dominant negative threonine to asparagine mutation at amino acid 17 |
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Tg(Fabpl-RAC1-T17N)1Jig expression driven by
1 gene
Transgene expression driven by:
| Organism |
Driver Gene |
Homolog in Mouse |
Note |
| rat |
Fabp1 (24360) |
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Mutation details: A human RAC1 gene carrying a dominant negative threonine to asparagine mutation at amino acid 17 was used for the transgene. Nucleotides -596 to +21 from rat Fabpl were used to drive expression of the transgene in intestinal epithelium.
(J:62539)
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| Mouse strains and cell lines
available from the International Mouse Strain Resource
(IMSR) |
| Carrying this Mutation: |
Mouse Strains: 0 strains available
Cell Lines: 0 lines available
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Transgenic animals exhibited abnormal morphology of jejunal crypt-villus units, inhibition of epithelial differentiation, and slowing of epithelial migration.
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| Original: |
J:62539 Stappenbeck TS, et al., Rac1 mutations produce aberrant epithelial differentiation in the developing and adult mouse small intestine. Development. 2000 Jun;127(12):2629-42 |
| All: |
1 reference(s) |
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Analysis Tools
