Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Nodaltm3Rob
Name:	nodal growth differentiation factor; targeted mutation 3, Elizabeth J Robertson
MGI ID:	MGI:2388004
Synonyms:	Nodaldelta, Nodaldeltanode
Gene:	Nodal  Location: Chr10:61253751-61261117 bp, + strand  Genetic Position: Chr10, 32.21 cM
Alliance:	Nodaltm3Rob page

Germline Transmission:	Earliest citation of germline transmission: J:79098
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Modified regulatory region, Null/knockout) Mutation:    Intragenic deletion   Mutation details: Expression of the endogenous gene was reduced by the deletion of a 2.7 kb enhancer region. The targeting vector contained a floxed hygromycin cassette, which was excised in vitro via the expression of cre recombinase. In situ hybridization showed normal expression in early gastrulation stages, with attenuated expression begining during the early somite stages. Robust expression was observed in the left lateral plate mesoderm. (J:79098)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 assay results
In Structures Affected by this Mutation:	3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Nodal Mutation:	41 strains or lines available

Original:	J:79098 Brennan J, et al., Nodal activity in the node governs left-right asymmetry. Genes Dev. 2002 Sep 15;16(18):2339-44
All:	2 reference(s)