Summary | Mutation origin | Mutation description | Expression | Phenotypes | Disease models | Find Mice (IMSR) | References

Symbol:	Tbx5tm1Jse
Name:	T-box 5; targeted mutation 1, Jonathan G Seidman
MGI ID:	MGI:2387850
Synonyms:	Tbx5lox
Gene:	Tbx5  Location: Chr5:119970733-120023284 bp, + strand  Genetic Position: Chr5, 60.42 cM
Alliance:	Tbx5tm1Jse page

Germline Transmission:	Earliest citation of germline transmission: J:71845
Parent Cell Line:	Not Specified (ES Cell)
Strain of Origin:	Not Specified

Allele Type:    Targeted (Conditional ready, No functional change) Mutation:    Insertion   Mutation details: LoxP sites flanking exon 3 and an upstream neo cassette were introduced to the gene via homologous recombination. A loxP site and a neo cassette were inserted upstream of the flanked exon. (J:71845)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	40 assay results
In Structures Affected by this Mutation:	13 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Tbx5 Mutation:	28 strains or lines available

Original:	J:71845 Bruneau BG, et al., A murine model of Holt-Oram syndrome defines roles of the T-box transcription factor Tbx5 in cardiogenesis and disease. Cell. 2001 Sep 21;106(6):709-21
All:	24 reference(s)