Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Dkk1tm1Lmgd
Name:	dickkopf WNT signaling pathway inhibitor 1; targeted mutation 1, Laboratory of Mammalian Genes and Development, Heiner Westphal
MGI ID:	MGI:2387760
Synonyms:	Dkk1-
Gene:	Dkk1  Location: Chr19:30523276-30526896 bp, - strand  Genetic Position: Chr19, 25.16 cM, cytoband C2
Alliance:	Dkk1tm1Lmgd page

Germline Transmission:	Earliest citation of germline transmission: J:71787
Parent Cell Line:	R1 (ES Cell)
Strain of Origin:	(129X1/SvJ x 129S1/Sv)F1-Kitl+

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The entire coding region of the gene was replaced with a neomycin resistance cassette via homologous recombination. Homozygous mutants were identified by Southern blot analysis. (J:71787)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	315 assay results 1 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	20 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Dkk1 Mutation:	17 strains or lines available

Original:	J:71787 Mukhopadhyay M, et al., Dickkopf1 is required for embryonic head induction and limb morphogenesis in the mouse. Dev Cell. 2001 Sep;1(3):423-34
All:	29 reference(s)