Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol: Rps6kb1tm1Gtho Name: ribosomal protein S6 kinase, polypeptide 1; targeted mutation 1, George Thomas MGI ID: MGI:2387472 Synonyms: S6K1- Gene: Rps6kb1  Location: Chr11:86389697-86435631 bp, - strand  Genetic Position: Chr11, 51.82 cM Alliance: Rps6kb1tm1Gtho page

Beta cell and islet size in Tg(Ins2-Akt1*)3Mbb/0, Rps6kb1tm1Gtho/Rps6kb1tm1Gtho, and double mutant mice Show the 1 phenotype image(s) involving this allele.

Germline Transmission:	Earliest citation of germline transmission: J:52107
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: 1.2 kb of genomic sequence, including regions encoding the conserved serine threonine kinase catalytic subdomains 8 through 10, was replaced with a neomycin selection cassette by homologous recombination. Western blot analysis of homozygous mutant mice using two antibodies directed to the amino and carboxy termini showed an absence of protein. A kinase phosphorylation assay showed no activity in homozygous mutant mice verifying a complete functional ablation. (J:52107)

View phenotypes and curated references for all genotypes (concatenated display).

In Mice Carrying this Mutation:	2 RNA-Seq or microarray experiment(s)
In Structures Affected by this Mutation:	5 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Rps6kb1 Mutation:	55 strains or lines available

Original:	J:52107 Shima H, et al., Disruption of the p70(s6k)/p85(s6k) gene reveals a small mouse phenotype and a new functional S6 kinase. EMBO J. 1998 Nov 16;17(22):6649-59
All:	52 reference(s)