Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Gpd2tm1Lbr
Name:	glycerol phosphate dehydrogenase 2, mitochondrial; targeted mutation 1, Laura J Brown
MGI ID:	MGI:2387347
Synonyms:	Gdm-, mGPD o/o
Gene:	Gpd2  Location: Chr2:57127690-57260731 bp, + strand  Genetic Position: Chr2, 31.66 cM
Alliance:	Gpd2tm1Lbr page

Germline Transmission:	Earliest citation of germline transmission: J:78828
Parent Cell Line:	RW-4 (ES Cell)
Strain of Origin:	129X1/SvJ

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of exons 5 and 6 with a neomycin resistance cassette via homologous recombination, resulting in a frameshift and premature translation termination in exon 7. Gene expression was absent in homozygous mutant animals as demonstrated by Western blot analysis of samples prepared from brown adipose tissue. The same samples were assayed for enzyme activity. Samples taken from homozygous mice exhibited negligible amounts of enzyme activity. (J:78828)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

3 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Gpd2 Mutation:	84 strains or lines available

Original:	J:78828 Brown LJ, et al., Normal thyroid thermogenesis but reduced viability and adiposity in mice lacking the mitochondrial glycerol phosphate dehydrogenase. J Biol Chem. 2002 Sep 6;277(36):32892-8
All:	4 reference(s)