Summary | Mutation origin | Mutation description | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Blktm1Tara
Name:	B lymphoid kinase; targeted mutation 1, Alexander Tarakhovsky
MGI ID:	MGI:2386868
Synonyms:	blk-
Gene:	Blk  Location: Chr14:63610285-63654486 bp, - strand  Genetic Position: Chr14, 33.25 cM
Alliance:	Blktm1Tara page

Germline Transmission:	Earliest citation of germline transmission: J:60221
Parent Cell Line:	E14.1 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: Sequences encoding the essential portion of the kinase domain in exon 8 were replaced with a neomycin resistance gene via homologous recombination. Gene expression was not detected in splenic B-cells from homozygous mutant animals via Northern blot, but RT-PCR analysis detected transcripts containing exons 1-4. However, Western blot using antibodies directed against the N-terminal region of the protein did not detect any translation product from the truncated transcript. (J:60221)

View phenotypes and curated references for all genotypes (concatenated display).

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 1 strain available      Cell Lines: 0 lines available
Carrying any Blk Mutation:	27 strains or lines available

Original:	J:60221 Texido G, et al., The B-cell-specific Src-family kinase Blk is dispensable for B-cell development and activation. Mol Cell Biol. 2000 Feb;20(4):1227-33
All:	6 reference(s)