Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Xbp1tm1Glm
Name:	X-box binding protein 1; targeted mutation 1, Laurie H Glimcher
MGI ID:	MGI:2386788
Synonyms:	XBP-1-
Gene:	Xbp1  Location: Chr11:5470659-5475893 bp, + strand  Genetic Position: Chr11, 3.61 cM
Alliance:	Xbp1tm1Glm page

Germline Transmission:	Earliest citation of germline transmission: J:59916
Parent Cell Line:	D3 (ES Cell)
Strain of Origin:	129S2/SvPas

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 0.8 kb genomic region between exons 1 and 2 was replaced with a neomycin resistance cassette via homologous recombination resulting in a shift in the downstream reading frame. Northern blot analysis of homozygous mutant embryos did not detect wild-type transcript, but instead detected a larger mutant transcript which contained the neo insert. Western blot of fetal livers did not detect protein product in homozygous mutants. (J:59916)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Xbp1 Mutation:	28 strains or lines available

Original:	J:59916 Reimold AM, et al., An essential role in liver development for transcription factor XBP-1. Genes Dev. 2000 Jan 15;14(2):152-7
All:	13 reference(s)