Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | References

Symbol:	Satb1tm1Kos
Name:	special AT-rich sequence binding protein 1; targeted mutation 1, Terumi Kohwi-Shigematsu
MGI ID:	MGI:2386676
Gene:	Satb1  Location: Chr17:52043215-52140318 bp, - strand  Genetic Position: Chr17, 26.81 cM
Alliance:	Satb1tm1Kos page

Germline Transmission:	Earliest citation of germline transmission: J:61085
Parent Cell Line:	E14 (ES Cell)
Strain of Origin:	129P2/OlaHsd

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: A 10.9 kb region containing exons 1 through 5 was replaced by a neomycin selection cassette inserted at the endogenous locus via homologous recombination. The deleted exons encoded 213 amino acids, including the intitiator methionine. RT-PCR and Western blot analyses of thymus extracts showed an absence of endogenous transcript and protein in homozygous mutant mice. (J:61085)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

4 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Satb1 Mutation:	48 strains or lines available

Original:	J:61085 Alvarez JD, et al., The MAR-binding protein SATB1 orchestrates temporal and spatial expression of multiple genes during T-cell development. Genes Dev. 2000 Mar 1;14(5):521-35
All:	9 reference(s)