Summary | Mutation origin | Mutation description | Expression | Phenotypes | Find Mice (IMSR) | Notes | References

Symbol:	Renbptm1Csch
Name:	renin binding protein; targeted mutation 1, Christian Schmitz
MGI ID:	MGI:2386397
Synonyms:	RnBP-
Gene:	Renbp  Location: ChrX:72965727-72974456 bp, - strand  Genetic Position: ChrX, 37.49 cM
Alliance:	Renbptm1Csch page

Germline Transmission:	Earliest citation of germline transmission: J:62268
Parent Cell Line:	Other (see notes) (ES Cell)
Strain of Origin:	129/SvEmcTer

Allele Type:    Targeted (Null/knockout) Mutations:    Insertion, Intragenic deletion   Mutation details: The gene was disrupted by replacement of a 1 kb region including part of exon 5 and exon 6 with a neomycin resistance cassette via homologous recombination. The targeted mutation results in deletion of sequences encoding a leucine zipper motif, which is required for interaction with renin. Homozygous mutant animals did not express gene transcripts as determined by Northern blot analysis of kidney RNA. (J:62268)

View phenotypes and curated references for all genotypes (concatenated display).

In Structures Affected by this Mutation:

1 anatomical structure(s)

Mouse strains and cell lines available from the International Mouse Strain Resource (IMSR)
Carrying this Mutation:	Mouse Strains: 0 strains available      Cell Lines: 0 lines available
Carrying any Renbp Mutation:	5 strains or lines available

Original:	J:62268 Schmitz C, et al., Normal blood pressure and plasma renin activity in mice lacking the renin-binding protein, a cellular renin inhibitor. J Biol Chem. 2000 May 19;275(20):15357-62
All:	1 reference(s)